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Seven viruses including EBV, HBV, HCV, KSHV, HIV, HTLV, and HPV have been classified as Group 1 human carcinogens, according to the journal Recent Results in Cancer Research in a study published in 2014. The Center for the Biology of Chronic Disease (CBCD) reviews the medical literature and explains the relationship between this classification and Dr. Hanan Polanskys discovery.
Rochester, NY (PRWEB) July 04, 2014
More than 10 years ago, a ground breaking book entitled Microcompetition with Foreign DNA and the Origin of Chronic Disease was written by Dr. Hanan Polansky. It presented a unique theory on how latent viruses can cause cancer.
Today, Dr. Chen and colleagues confirm some of Dr. Polanskys research. Seven viruses have been classified as Group 1 human carcinogens (cancer causing agents) by the International Agency for Research on Cancer (IARC). These viruses include Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C virus (HCV), Kaposi's sarcoma herpes virus (KSHV), human immunodeficiency virus, type-1 (HIV-1), human T cell lymphotrophic virus, type-1 (HTLV-1), and human papillomavirus (HPV). (1) Dr. Chen and colleagues are from the Genomics Research Center, Academia Sinica, in Taipei, Taiwan.
Dr. Chen wrote that Some viruses may cause more than one cancer, while some cancers may be caused by more than one virus. However, only a proportion (only some) of persons infected by these oncogenic (cancer causing) viruses will develop specific cancers. A series of studies have been carried out to assess the viral, host, and environmental cofactors of EBV-associated nasopharyngeal carcinoma, HBV/HCV-associated hepatocellular carcinoma, and HPV-associated cervical carcinoma. Persistent infection and high viral load are important risk predictors of these virus-caused cancers. (1) That is, a chronic infection with these viruses in high numbers is a recognized cause of cancer.
Dr. Polanskys work in 2003 identified latent viruses as the origin of many chronic diseases, such as cancer, atherosclerosis, stroke, obesity, diabetes, multiple sclerosis, lupus, thyroiditis, osteoarthritis, rheumatoid arthritis, and alopecia. (See Microcompetition with Foreign DNA and the Origin of Chronic Disease, published in 2003) (2) Specifically, Dr. Polanskys work explains how foreign DNA fragments, created by latent viruses, can cause these, and many other major diseases. The book has been read by more than 5,000 scientists around the world, and has been reviewed in more than 20 leading scientific journals.
Dr. Polanskys theory, discusses how these latent viruses that include foreign DNA fragments called N-boxes, are causing most major diseases. For example, The theory describes the effect of Foreign DNA fragments that include the cis-regulatory element, called an N-box, on transcription of cellular genes. Consider foreign N-boxes that entered the body naturally, through, for instance, an infection or digestion, or artificially, through, for instance, an injection of some treatment. The foreign N-boxes attract the transcription complex GABPp300. Since the complex is a scarce genetic resource, the foreign N-boxes decrease the availability of this complex to cellular genes. (2)
What is the result of Microcompetition?
The genes that are transactivated by the GABPp300 complex produce fewer proteins, and the genes that are suppressed by this complex produce more proteins. The abnormal levels of these cellular proteins cause a disease. It is interesting that many common viruses that establish a latent infection have strong N-boxes in their promoter/enhancer. They include the Epstein-Barr virus (EBV), Cytomegalovirus (CMV), Herpes Simplex virus (HSV), Varicella Zoster virus (VZV), Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), and the Human Papillomavirus (HPV). In fact, the CMV has the strongest promoter/enhancer known to science. Liu et al. showed that the CMV promoter/enhancer, which includes the N-box, is more than 150-fold stronger than the promoter of the platelet-derived growth factor-b chain (PDGF-b) gene. (See Pharmacology & Pharmacy, from March 2014) (3). The Microcompetition theory predicts that a latent infection with CMV will cause a decrease in PDGF-b transcription, a decrease in the concentration of the PDGF-b protein, and disease.
For a better understanding of latent viruses and their impact on chronic disease processes, including cancer, the CBCD encourages government officials, healthcare managers, physicians, virologists, biologists, geneticists, and scientists to obtain a copy of Dr. Hanan Polansky's book and read it. A free copy of the book can be downloaded from the CBCD website here: http://www.cbcd.net/Book.php.
Dr. Polanskys book received high praise from leading scientists. For example, Dr. Q. Ping Dou, PhD said Not only does the book present a strong theory to unify the cause of many diverse disease states, the book itself represents an aspect lacking in the field of medical science, an attempt to unify observations into coherent theories. Dr. Dou is from the Barbara Ann Karmanos Cancer Institute, and is a Professor at the Department of Pathology, School of Medicine, Wayne State University (See the CBCD, from 2008) (4). More than fifty additional reviews recommending the book can be found here: http://www.cbcd.net/reviews.htm.
The CBCD endorses Dr. Polanskys theory and invites interested parties to contact us on this issue.
For more information on the Center for the Biology of Chronic Disease, or to schedule an interview with Dr. Polansky, please visit http://www.cbcd.net or call 585-250-9999.
(1) Chen CJ1, Hsu WL, Yang HI, Lee MH, Chen HC, Chien YC, You SL. Epidemiology of virus infection and human cancer. Published in 2014. http://www.ncbi.nlm.nih.gov/pubmed/24008291
(2) Microcompetition with Foreign DNA and the Origin of Chronic Disease. Published 2003.http://www.cbcd.net/Book.php
(3) Gene-Eden-VIR is Antiviral: Results of a Post marketing clinical study. Published in September 2013. http://www.scirp.org/journal/PaperInformation.aspx?PaperID=36101#.U6KOppSSz90
(4) CBCD Book Reviews http://www.cbcd.net/reviews.htm
The Center for the Biology of Chronic Disease (CBCD, http://www.cbcd.net) is a research center recognized by the IRS as a 501(c)(3) non-for-profit organization. The mission of the CBCD is to advance the research on the biology of chronic diseases, and to accelerate the discovery of treatments for these diseases.
The CBCD published the Purple book entitled Microcompetition with Foreign DNA and the Origin of Chronic Disease written by Dr. Hanan Polansky. The book presents Dr. Polanskys highly acclaimed scientific theory on the relationship between the DNA of latent (chronic) viruses and the onset of chronic diseases.
Dr. Polanskys book is available as a free download from the CBCD website.
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